目的探讨唐草片是否影响艾滋病病毒(Human immunodeficiency virus,HIV)感染者中依非韦伦的药代动力学。方法在单纯用高效抗反转录病毒治疗之前,以及联合服用唐草片之后两周采血,采集服用依非韦伦后0、0.5、1、2、3、4、5、6、8、12、16及24小时的标本,检测依非韦伦血浆浓度,并采用DAS软件计算药代动力学参数。结果 11例合格的HIV感染者服用唐草片前依非韦伦的曲线下面积(Area under the curve,AUC)为40.6mg/Lh,Cmax为4.2mg/L,Tmax为4.36h,t1/2z为18.3h;同时服用唐草片后,依非韦伦的AUC为40.7mg/Lh,Cmax为4.1mg/L,Tmax为4.46h,t1/2z为16.4h。两组之间各参数均无显著差异。结论唐草片对HIV感染者中依非韦伦的药代动力学无影响。
This study was carried out in the Wistar rats to investigate the effect of Tang herb on the pharmacokinetics of the antiretroviral drug lopinavir （LPV） following single oral administration. Rats were randomly divided into LPV group （36 mg/kg） and LPV combining with Tang herb group （LPV： 36 mg/kg, Tang herb： 864 mg/kg）. The blood concentrations of lopinavir at 0, 0.5, 1, 2, 4, 8, 10, 12, 14, 16, 22 h after administration were determined by HPLC and the pharmacokinetic parameters were investigated. The results showed that Tang herb significantly increased the Cmax and A UC （P〈0.05） while slightly increased the t1/2z and Tmax of lopinavir （P〉0.05）. The present study suggests that Tang herb may delay the absorption, increase the time to reach the maximum concentration, and improve the bioavailability of LPV. Further evaluation of the possible interaction mechanism between Tang herb and LPV needs to be studied.
